| ACM | Association for Computing Machinery |
| ACR | American College of Radiology |
| AHA | American Hospital Association |
| AI | Artificial Intelligence (as in the AI Lab at MIT) |
| AMA | American Medical Association |
| ANSI | American National Standards Institute |
| ASCII | American Standard Code for Information Interchange |
| ASP | Application Service Provider (easily confused with Active Server Pages, a format for web site programming created by Microsoft) |
| ATM | Asynchronous Transfer Mode |
| BBN | Bolt, Beranek and Newman |
| BBN | Buckingham, Brown and Nichols |
| BIND | Berkeley Internet Name Domain |
| BWH | Brigham and Women's Hospital |
| CCITT | Comité Consultatif International Télégraphique et Téléphonique |
| CEO | Chief Executive Officer |
| CF | Computed Fluoroscopy |
| CFO | Chief Financial Officer |
| CHF | Congestive Heart Failure |
| CIO | Chief Information Officer= |
| COBOL | Common Business Oriented Language |
| CORBA | Common Object Request Broker Architecture |
| CR | Computed Radiography |
| CSS | Cascading Style Sheets |
| CT | Computed Tomography |
| DICOM | Digital Image and COMmunication protocol |
| DNS | Domain Name Server |
| DRG | Disease Related Group |
| FSF | Free Software Foundation |
| FTC | Federal Trade Commission |
| FTP | File Transfer Protocol |
| GNU | Gnu's Not Unix |
| GPL | General Public License (sometimes GNU Public License) |
| HBS | Harvard Business School |
| HIMSS | Healthcare Information and Management Systems Society |
| HIS | Healthcare Information Systems |
| HMO | Health Maintenance Organization |
| HTML | HyperText Markup Language |
| HTTP | HyperText Transfer Protocol |
| IANA | Internet Assigned Numbers Authority |
| ICANN | Internet Corporation for Assigned Names and Numbers |
| IEC | International Electrotechnical Commission |
| IEEE | Institute of Electrical and Electronics Engineers |
| IETF | Internet Engineering Task Force |
| IP | Internet Protocol |
| IPO | Initial Public Offering |
| IRB | Institutional Review Board |
| IS | Information Services |
| ISDN | Integrated Services Digital Network |
| ISO | Not an Acronym. See About ISO |
| ISOC | Internet SOCiety |
| IT | Information Technology |
| ITU | International Telecommunications Union |
| LAN | Local Area Network |
| LISP | LISt Processing |
| MGH | Massachusetts General Hospital |
| MIT | Massachusetts Institute of Technology |
| MP3 | MPEG Layer 3 (MPEG is Moving Picture Experts Group) |
| MRI | Magnetic Resonance Imaging |
| NCI | National Cancer Institutes |
| NEMA | National Electrical Manufacturing Association |
| NIH | National Institute of Health |
| NLM | National Library of Medicine |
| NM | Nuclear Medicine |
| NMR | Nuclear Magnetic Resonance |
| OSI | Open Systems Interconnection |
| PACS | Picture Archiving and Communications System |
| PCP | Primary Care Provider |
| PTC | Partners Telemedicine Center |
| RFC | Request for Comment |
| RFP | Request for Proposal |
| RIS | Radiology Information System |
| RSNA | Radiological Society of North America |
| SEC | Securities and Exchange Commission |
| SMTP | Simple Mail Transfer Protocol |
| SNMP | Simple Network Managment Protocol | |
| TCP/IP | Transfer Control Protocol/Internet Protocol |
| URI | Universal Resource Identifier |
| URL | Universal Resource Locater |
| VAR | Value Added Reseller |
| VPN | Virtual Private Network |
| WWHQ | World Wide Head Quarters |
| XML | eXtensible Markup Language |
| XSL | eXtensible Style Sheets |